U-RHYTHM Publications

 

FIRST PAPER PUBLISHED from the horizon 2020 ULTRADIAN hormone diagnostics STUDY

High-resolution daily profiles of tissue adrenal steroids by portable automated collection. Sci Transl Med 2023. PMID: 37343084

We use U-RHYTHM to obtain high-resolution profiles of tissue adrenal steroids over 24 hours in 214 healthy volunteers - and developed “dynamic markers” of normality.

First use of u-rhythm on babies and children

The Peacock study: feasibility of the dynamic characterisation of the paediatric hypothalamic-pituitary-adrenal function during and after cardiac surgery. BMC Cardiovasc Disord 2020. PMID: 32450805

Here we evaluate the dynamic cortisol and cortisone response to heart surgery in children.

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First use of u-rhythm outside the clinic

Continuous Free Cortisol Profiles – Circadian Rhythms In Healthy Men. J Clin Endocrinol Metab 2019. PMID: 31355884

In this study we show the dynamics of 24-hour measurements of subcutaneous free cortisol in in 8 healthy male individuals for 3 successive days using the U-RHYTHM portable device – outside a research setting, and in everyday life.

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Blood vs subcutaneous interstitial biochemistry dynamics

Continuous Free Cortisol Profiles in Healthy Men - Validation of Microdialysis Method. J Clin Endocrinol Metab. 2020. PMID: 31529059

In this article we show good correlation between the dynamic responses of total and free serum cortisol (collected by venous cannulation and intravenous microdialysis, respectively) and subcutaneous interstitial free cortisol levels (collected using the U-RHYTHM portable device).

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Tracking cortisol profiles in pregnant women using U-RHYTHM

Pulsatility of glucocorticoid hormones in pregnancy: Changes with gestation and obesity Clin Endocrinol (Oxf). 2018. PMID: 29314170

Here we demonstrate cortisol pulsatility in interstitial fluid of pregnant women and show that pulse frequency alters with advancing gestation.

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First prototype (the blue box)

Automated 24-hours sampling of subcutaneous tissue free cortisol in humans. J Med Eng Technol. 2013. PMID: 23547774

Here we describe the first U-RHYTHM prototype. Subcutaneous biochemistry is successfully collected every 10-min from 2 healthy male volunteers over a full 24hr period (in the hospital setting). Sample analysis reveals distinct circadian patterns of free cortisol in tissues.